Toxicology and Environmental Medicine (GRAD)
The Curriculum in Toxicology and Environmental Medicine administers a degree program leading to the award of the Ph.D. in toxicology. The curriculum is an interdisciplinary program, and its faculty is drawn from various administrative units of the schools of medicine, pharmacy, and public health. The training faculty also includes scientists at government laboratories on campus or in the Research Triangle Park (e.g., EPA, NIEHS). The research interests of the faculty include most areas of toxicology, with particular emphasis on understanding the links between the environment and health risks, the mode of action of toxicants and disease pathogenesis, and how emerging knowledge could be translated into prevention strategies, new therapeutic interventions, and an improved scientific basis for risk assessment.
The main areas of research concentration are molecular carcinogenesis, mechanistic toxicology, neurotoxicology, cardiopulmonary toxicology, hepatic toxicology, computational toxicology, developmental toxicology, immunotoxicology, drug and xenobiotic metabolism, and ethanol toxicology. Multidisciplinary efforts are directed at environmental toxicology, systems biology, animal models of human diseases, translational research, and biomarkers. The faculty generally does not conduct research in the areas of aquatic toxicology, forensic toxicology, the ecological aspects of toxicology, or studies in invertebrate systems. The research activities of the Curriculum in Toxicology are conducted in the laboratory facilities assigned to each faculty member by a participating administrative unit.
Applications
Students with interest in the Ph.D. degree in toxicology must apply for Graduate School admission through the Biological and Biomedical Sciences Program. Applications are considered from students who have received or expect to receive a B.S./B.A. or an M.S. degree in a scientific discipline. A desirable background for predoctoral studies in toxicology includes courses in biological sciences (including histology and animal physiology), in chemistry (including analytical and organic), and in mathematics through calculus, although all of these are not absolutely essential. A strong course in general biochemistry accelerates the student's progress. Applicants are evaluated on the basis of undergraduate (and graduate) academic performance, and letters of recommendation. Students are accepted on the basis of their achievement and potential. Prior research experience is strongly considered in the assessment of qualifications for admission.
Financial Aid
The curriculum seeks to fund predoctoral students each year. All applicants are considered for financial aid awards.
Toxicology, Doctoral Program (Ph.D.)
The Curriculum in Toxicology and Environmental Medicine administers a degree program leading to the award of the Ph.D. in toxicology. The curriculum is an interdisciplinary program, and its faculty is drawn from various administrative units of the schools of medicine, pharmacy, and public health. The training faculty also includes scientists at government laboratories on campus or in the Research Triangle Park (e.g., EPA, NIEHS). The research interests of the faculty include most areas of toxicology, with particular emphasis on understanding the links between the environment and health risks, the mode of action of toxicants and disease pathogenesis, and how emerging knowledge could be translated into prevention strategies, new therapeutic interventions, and an improved scientific basis for risk assessment.
The main areas of research concentration are molecular carcinogenesis, mechanistic toxicology, neurotoxicology, cardiopulmonary toxicology, hepatic toxicology, computational toxicology, developmental toxicology, immunotoxicology, drug and xenobiotic metabolism, and ethanol toxicology. Multidisciplinary efforts are directed at environmental toxicology, systems biology, animal models of human diseases, translational research, and biomarkers. The faculty generally does not conduct research in the areas of aquatic toxicology, forensic toxicology, the ecological aspects of toxicology, or studies in invertebrate systems. The research activities of the Curriculum in Toxicology are conducted in the laboratory facilities assigned to each faculty member by a participating administrative unit.
Course Requirements
| Code | Title | Hours |
|---|---|---|
| Core Courses | ||
| PATH 713 | Molecular and Cellular Pathophysiological Basis of Disease: Mechanisms of Disease | 3 |
| PATH 714L | Molecular and Cellular Pathophysiological Basis of Disease: Laboratory I | 2 |
| TOXC 707 | Advanced Toxicology | 3 |
| TOXC 721 | Toxicology Seminar II | 1 |
| TOXC 722 | Toxicology Seminar III 1 | 6 |
| TOXC 749 | Biochemical Toxicology | 3 |
| TOXC 821 | Scientific Writing | 1 |
| Complete one of the following courses: | 3 | |
| Biostatistics for Laboratory Scientists | ||
| Introduction to Statistical Modeling | ||
| Principles of Statistical Inference | ||
| Electives | ||
| A minimum of two elective didactic courses from list below. | 3 | |
| Thesis/Substitute or Dissertation Course | ||
| At least 3 hours, each semester, of: 2 | 18+ | |
| Research in Toxicology | ||
or TOXC 994 | Doctoral Research and Dissertation | |
| Minimum Hours | 40 | |
- 1
TOXC 722 must be taken every semester for 1 credit hour.
- 2
TOXC 901 after joining program in year 2 and until passing written qualifying exam. TOXC 994 after passing qualifying exam.
| Code | Title | Hours |
|---|---|---|
| Electives 1 | ||
| BCB 710 | Bioinformatics Colloquium | 1 |
| BIOL 631 | Advanced Molecular Biology | 4 |
| CBPH 852 | Experimental Physiology of Human Health and Disease | 4 |
| CBPH 853 | Experimental Physiology of Human Health and Disease | 4 |
| ENVR 470 | Environmental Risk Assessment | 3 |
| ENVR 601 | Epidemiology for Environmental Scientists | 3 |
| ENVR 630 | Systems Biology in Environmental Health | 3 |
| ENVR 730 | Computational Toxicology and Exposure Science | 3 |
| GNET 621 | Principles of Genetic Analysis I | 3 |
| GNET 646 | Mouse Models of Human Disease | 1 |
| GNET 647 | Human Genetics and Genomics | 1 |
| MCRO 614 | Immunobiology | 3 |
| PHCO 701 | Introduction to Molecular Pharmacology | 3 |
- 1
This recommended list is not exhaustive and availability of courses may change, please look at courses provided by other BBSP providers; other courses can be taken based on student need or DGS recommendation.
Milestones
The following list of milestones (non-course degree requirements) must be completed; view this list of standard milestone definitions for more information.
- Doctoral Committee
- Doctoral Oral Comprehensive Exam
- Doctoral Written Exam
- Prospectus Oral Exam (Dissertation Proposal, includes written and oral components)
- Dissertation Defense
- Doctoral Dissertation Approved/Format Accepted
- Residence Credit
- Doctoral Exit Survey
Professors
Shawn Ahmed
Neil Alexis
Kim R. Brouwer
Rebecca Fry
Avram Gold
Ilona Jaspers
Beverly Koller
Leena A. Nylander-French
David Peden
Dale A. Ramsden
Scott H. Randell
Matthew Redinbo
Shehzad Z. Sheikh
Miroslav Styblo
Alexander Tropsha
Cyrus Vaziri
Paul B. Watkins
Bernard E. Weissman
Mark Zylka
Associate Professors
Erin Baker
Folami Ideraabdullah
Samir Kelada
Jeffrey M. Macdonald
Timothy P. Moran
Celia Shiau
Assistant Professors
Edward Bahnson
Leon Coleman Jr.
Elizabeth Corteselli
Klarissa Dawniette Jackson
Julia Rager
Meghan Rebuli
Imran Rizvi
Johanna Smeekens
Gregory Smith
Faculty Affiliates from Other Research Institutions
National Institute of Environmental Health Sciences
Kelly Ferguson
Stephen Ferguson
Michael B. Fessler
G. Jean Harry
Gregory S. Travlos
Carmen J. Williams
North Carolina Central University
Antonio Baines
U.S. Environmental Protection Agency
Brian Chorley
Hisham El-Masri
Aimen K. Farraj
Stephen Gavett
M. Ian Gilmour
Mehdi A. Hazari
David Herr
Erin Hines
Thomas Jackson
Yong Ho Kim
Urmila P. Kodavanti
Elizabeth Medlock Kakaley
Colette Miller
John M. Rogers
James M. Samet
Haiyan Tong
Cavin Ward-Caviness
TOXC
Advanced Undergraduate and Graduate-level Courses
Emphasizes topics of current research interest relative to the genesis of environmentally caused and genetically based birth defects. One two-hour session per week (evening).
Graduate-level Courses
In this course, we will read, discuss and present primary research articles, from various research groups, in order to interpret the true meaning of recent scientific findings in the field of toxicology. A general understanding of Biology, Chemistry and Human Health is required.
Introduces students to the major areas of pharmacology and physiology and serves as a basis for more advanced courses. Three lecture hours a week.
Cellular and physiological basis of toxicity of environmental chemicals, with emphasis on inhalation toxicology, developmental toxicology, immunotoxicology, radiation toxicology, renal toxicology, and neurotoxicology. Three lecture hours per week.
Student-conducted presentations and discussions of recent advances in toxicology; emphasis on critical evaluation of published investigations and on organization and oral delivery of presentations. One hour per week.
Presentations by outside invited speakers, local faculty, advanced graduate students, and postdoctoral trainees. Topics will cover all areas of research in toxicology. One hour per week.
Regulatory agency fundamentals, regulatory process for drug, medical device, cosmetic and agrochemical products. Industry, regulatory agency representatives and consultants will be invited to speak directly about their regulatory policies, challenges, and expectations. Students will develop and present a regulatory submission package as part of a group project.
Required preparation, one course in biochemistry. Biochemical actions of toxicants and assessment of cellular damage by biochemical measurements. Three lecture hours per week.
A quantitative examination of the time course of absorption, distribution, metabolism, excretion, and biologic effects of agents of toxicologic interest. Three lecture hours per week.
Permission of the instructor. Survey of classical and current literature on selected critical issues in carcinogenesis. Students discuss experimental methods and observations as well as theories and generalizations. Two seminar hours a week.
Doctoral candidacy in toxicology required. Workshops on scientific writing with special emphasis on fellowship applications and the doctoral research proposal. Students work on several written assignments and are expected to complete a draft of their proposals by the end of the semester.
May be repeated. Students register in this course as they formulate their doctoral research projects.
Students acquire practical experience through an internship program at a non-academic institution where knowledge in toxicology is applied toward its mission. They subsequently prepare a capstone monograph (thesis substitute) that reports on their individualized experience, a requirement for the MPS in Toxicology.
May be repeated. Hours and credits to be arranged.
May be repeated. Hours and credits to be arranged.
Curriculum in Toxicology
Director of the Curriculum in Toxicology & Environmental Medicine
Meghan Rebuli
