TOXICOLOGY (TOXC)

Emphasizes topics of current research interest relative to the genesis of environmentally caused and genetically based birth defects. One two-hour session per week (evening).

In this course, we will read, discuss and present primary research articles, from various research groups, in order to interpret the true meaning of recent scientific findings in the field of toxicology. A general understanding of Biology, Chemistry and Human Health is required.

Introduces students to the major areas of pharmacology and physiology and serves as a basis for more advanced courses. Three lecture hours a week.

Cellular and physiological basis of toxicity of environmental chemicals, with emphasis on inhalation toxicology, developmental toxicology, immunotoxicology, radiation toxicology, renal toxicology, and neurotoxicology. Three lecture hours per week.

Student-conducted presentations and discussions of recent advances in toxicology; emphasis on critical evaluation of published investigations and on organization and oral delivery of presentations. One hour per week.

Presentations by outside invited speakers, local faculty, advanced graduate students, and postdoctoral trainees. Topics will cover all areas of research in toxicology. One hour per week.

Regulatory agency fundamentals, regulatory process for drug, medical device, cosmetic and agrochemical products. Industry, regulatory agency representatives and consultants will be invited to speak directly about their regulatory policies, challenges, and expectations. Students will develop and present a regulatory submission package as part of a group project.

Required preparation, one course in biochemistry. Biochemical actions of toxicants and assessment of cellular damage by biochemical measurements. Three lecture hours per week.

A quantitative examination of the time course of absorption, distribution, metabolism, excretion, and biologic effects of agents of toxicologic interest. Three lecture hours per week.

Permission of the instructor. Survey of classical and current literature on selected critical issues in carcinogenesis. Students discuss experimental methods and observations as well as theories and generalizations. Two seminar hours a week.

Doctoral candidacy in toxicology required. Workshops on scientific writing with special emphasis on fellowship applications and the doctoral research proposal. Students work on several written assignments and are expected to complete a draft of their proposals by the end of the semester.

May be repeated. Students register in this course as they formulate their doctoral research projects.

Students acquire practical experience through an internship program at a non-academic institution where knowledge in toxicology is applied toward its mission. They subsequently prepare a capstone monograph (thesis substitute) that reports on their individualized experience, a requirement for the MPS in Toxicology.

May be repeated. Hours and credits to be arranged.

May be repeated. Hours and credits to be arranged.