Department of Microbiology and Immunology (GRAD)

Department of Microbiology and Immunology

http://med.unc.edu/microimm

WILLIAM E. GOLDMAN, Chair

The Department of Microbiology and Immunology, an administrative division of the School of Medicine, is a unit of The Graduate School. It offers instruction leading to the doctor of philosophy degree. A terminal master of science degree is granted only under special conditions. The department is highly regarded in many scientific disciplines, including immunology, microbial pathogenesis, virology, infectious diseases, host/pathogen interactions, molecular genetics, prokaryotic and eukaryotic molecular and cellular biology, and cancer biology. Research in the department is supported by funds from the University, the National Institutes of Health, the National Science Foundation, the American Cancer Society, and other private foundations and granting agencies.

Research Environment

The Department of Microbiology and Immunology consists of approximately 60 faculty members with active research laboratories, 70 graduate students, 60 postdoctoral scientists, 50 research staff, and 7 administrative staff, who together form a highly interactive, friendly, and collaborative community.

The department occupies the entire sixth floor (~25,000 net square feet) of the new Marsico Hall, as well as the recently renovated ninth floor of the Burnett-Womack Building. A significant number of faculty members who hold primary appointments in the department have laboratories in the nearby Lineberger Comprehensive Cancer Center as well as other departments within the School of Medicine and Gillings School of Global Public Health.

A variety of modern equipment is available in individual laboratories or shared by multiple users throughout the department. Well-equipped research laboratories are supplemented by specialized rooms dedicated to tissue culture, controlled temperature environments, BSL3 physical containment for research on microbial select agents, supervised animal care, etc. In addition, the University operates an extensive network of core facilities with major equipment and expert support staff, including flow cytometry, genomics, proteomics, oligonucleotide synthesis, DNA sequencing, X-ray crystallography, NMR, animal models (transgenic mouse and embryonic stem cell services), animal histopathology, bioinformatics, gene chips, confocal microscopy, electron microscopy, and mass spectrometry.

The department is fully supplied with high-speed Internet connections (both wired and wireless). University libraries provide electronic access to thousands of professional journals.

Admission

Students seeking admission to the Department of Microbiology and Immunology apply to BBSP, a common portal by which students interested in any of the 14 participating graduate programs begin their studies at UNC–Chapel Hill. To apply, prospective students should visit the BBSP and graduate admissions Web sites, fill out the online application, and select Microbiology and Immunology as their first choice of interest.

Financial Assistance

All Ph.D. students making satisfactory degree progress receive a stipend plus in-state tuition, fees, and health insurance. Funds are available from individual research grants, training grants, the department, and the University. Students are encouraged to apply for a predoctoral fellowship from the National Institute of Health, the National Science Foundation, or other organizations.

As is the case for all graduate students in the basic science departments of the UNC School of Medicine, education during the first year is under the guidance of the interdisciplinary Biological and Biomedical Sciences Program (BBSP). Students rotate through three different research laboratories of their choosing in year one. For students interested in microbiology and immunology, recommended classroom courses include Immunobiology (MCRO 614), Virology (MCRO 630), Microbial Pathogenesis I (MCRO 635), and Microbial Pathogenesis II (MCRO 640).

Upon choosing a dissertation laboratory and joining the Department of Microbiology and Immunology, students are provided with an outstanding learning environment, an opportunity to conduct cutting-edge research, and most importantly, thorough preparation for a successful career in science. The microbiology and immunology Ph.D. program is designed to provide a foundation of fundamental knowledge in modern microbiology and immunology, foster critical scientific thinking, develop written and oral communication skills, allow students to gain teaching experience, and offer opportunities to travel and present posters or talks at national meetings. Specific components of the microbiology and immunology Ph.D. training program include

  • Completion of six relevant courses, including two courses based directly on discussion of the primary literature (e.g., MCRO 710, MCRO 711, MCRO 712), and MCRO 795 are required. Students typically finish four of the six classes while in BBSP and the remainder during year two. There is no language requirement.
  • The written preliminary exam (also known as the doctoral written examination) consists of a research proposal, written in a format similar to an NIH pre- or postdoctoral fellowship proposal. The proposal is written whenever the student likes over the course of the spring semester.
  • The oral preliminary exam (also known as the doctoral oral examination) centers on the topic of the thesis project and provides an opportunity for the student to demonstrate his or her ability to discuss the fields of science related to the thesis proposal, as well as the ability to analyze problems and design experiments. The exam serves a dual purpose as the initial meeting of the thesis committee. Therefore, a separate decision to approve or disapprove the thesis project will occur in the same meeting.

Students must regularly attend weekly student and departmental seminars (MCRO 701) beginning in year two and present their research annually in the student seminar series beginning in year three.

Students act as teaching assistants for two semesters in department-approved courses, typically in years two and three.

Students form a dissertation committee in the middle of year three, obtain approval of their dissertation project, and meet annually with their committee to discuss research progress. Completion of sufficient original research for at least two first-author papers in high-quality peer reviewed journals is expected. As a minimum standard, to earn the Ph.D. degree we require that

  • A student must make meaningful contributions to and be an author on at least two manuscripts intended for publication in respected, high-quality professional journals or books,
  • At least one of the two manuscripts must be accepted for publication, and
  • Prior to the private Ph.D. defense, a student must have peer reviews returned for at least one first- (or co-first) author primary research manuscript.

Professors

Ralph Baric (76), Molecular Mechanisms of Virus Cross-Species Transmissibility and Systems Genetics and Pathogenesis1
Robert Bourret (64), Signal Transduction in Bacteria
Miriam Braunstein (80), Bacterial Pathogenesis, Molecular Genetics, Tuberculosis
Wesley Burks, Allergic Diseases, Mechanisms and Immunotherapy1
Bruce Cairns (93), Immune Response to Injury, Cellular Immunology, Transplantation1
Myron S. Cohen (55), Biology and Epidemiology of Transmission of STD Pathogens (Including HIV)1
Peggy Cotter (97), Microbial Pathogenesis, Molecular Genetics, Protein Secretion
Blossom Damania (79), Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8), Rhesus Monkey Rhadinovirus (RRV)
Jeff Dangl (87), Plant Genetics, Plant Microbiome, Plant Disease Resistance and Cell Death Control, Bacterial Type III Secretion Systems1
Toni Darville, Chlamydia Trachomatis Pathogenesis and Immune Protective Mechanisms1
Aravinda de Silva (73), Arthropod Vector-Borne Infectious Diseases and Microbial Pathogenesis
Dirk Dittmer (88), West Nile Virus (WNV) and Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8)
Gianpietro Dotti, Cancer Immunotherapy, Genetic Engineering; T-Cell Therapies, Tumor Microenvironment
Mark Heise (83), Molecular Genetics of Viral Pathogenesis1
J. Victor Garcia-Martinez (101), Viral Pathogenesis/Immunology, Humanized Mice, HIV/AIDS1
Peter H. Gilligan (51), Bacterial Toxins, Clinical Microbiology1
Jack Griffith (35), Chromosome Structure: Viruses and Their Host Cells
William E. Goldman (95), Pathogenesis of Respiratory Tract Infections: Histoplasmosis, Pertussis, and Plague
Ilona Jaspers (106), Respiratory Viruses, Host Innate Defense in the Respiratory Mucosa, Virus-Host Cell Interaction, Epithelial-Immune Cell Interaction, Environmental Effects1
Thomas Kawula (63), Bacterial Genetics, Microbial Pathogenesis
Stanley M. Lemon (59), Molecular Virology, Innate Immunity, Viral Carcinogenesis1
Zhi Liu (91), Biochemistry, Cell Biology, and Immunology of Hemidesmosome and Basement Membrane1
David M. Margolis (90), Regulation of Gene Expression, Molecular Biology of Retroviruses, HIV Pathogenesis1
Steven R. Meshnick (81), Malaria and Tick-Borne Diseases, Molecular Epidemiology, Pathogenesis, Drug Resistance1
Virginia L. Miller (96), Molecular and Genetic Analysis of Microbial Pathogenesis, Virulence Gene Regulation, Host-Pathogen Interactions1
Robert A. Nicholas (94), Antibiotic Resistance Mechanisms, Bacterial Genetics, Neisseria gonorrhoeae1
Joseph S. Pagano (14), Epstein-Barr Virus and Ubiquitin-Proteasomal Systems, Interferon Regulatory Factors, Invasion and Metastasis and Antiviral Drugs1
David Peden, Translational and Clinical Research in Environmental Lung Disease1
Matthew Redinbo, Structural and Chemical Biology of Host-Pathogen Contacts1
Howard M. Reisner (32), Immunogenetics of Human Plasma Proteins (Particularly IgG and Coagulant Factors VII and IX)1
R. Balfour Sartor (77), Etiology and Pathogenesis of Inflammatory Bowel Disease (especially Crohn's Disease and Associated Extraintestinal Manifestations)1
Jonathan Serody (82), Transplantation and Tumor Immunology1
Lishan Su (71), Immune Development, Viral Pathogenesis
Ronald Swanstrom (74), Molecular Biology and Pathogenesis of HIV1
Jenny P. Ting (50), Molecular Immunology, Transcription, Signal Transduction, Apoptosis, Neuroimmunology, Transplantation1
Roland Tisch (70), Immune Tolerance, T-Cell Antigen Recognition, T-Cell Mediated Autoimmunity, Tumor Antigen-Specific Genetic Vaccines, Type 1 Diabetes
Jennifer Webster-Cyriaque (84), Oral Manifestations of Systemic Disease, Host-Virus Interactions, Viral Oncogenesis, Viral Pathogenesis during Immunosuppression, Signal Transduction, Cellular Biology, Gene Expression1
William J. Yount (25), Genetic Control of Antibody Response and Gamma Globulin Synthesis in Humans1

Associate Professors

Edward J. Collins (69), Immune Recognition, T-Cell Activation, Host-Pathogen Interactions
Kristina DeParis (98), Neonatal/Pediatric Immunology; Pathogenesis of Infectious Diseases; HIV and Co-Infections
Tal Kafri, Development of HIV-Based Vector for Gene Therapy, the Epigenetics of HIV and HIV-1 Vectors, the Basic Biology of Nonintegrating HIV-1 and HIV-1 Vectors
Silva Markovic-Plese, Autoimmune Response in Multiple Sclerosis, New Immunomodulatory Therapies1
Glenn Matsushima (68), Molecular Neuroimmunology, Innate Immunity
Raymond Pickles (86), Respiratory Viruses, Host Innate Defense in the Airway, Virus-Host Cell Interactions, Gene Therapy for Cystic Fibrosis and Other Lung Diseases
Maureen Su, (108), Autoimmune Polyendocrinopathy Syndrome Type 1, Chronic Inflammatory Demyelinating Polyneuropathy, Diabetes1
Teresa Tarrant (109), Leukocyte Trafficking, Kinase Regulation of Chemokine Receptors, Inflammatory Models of Autoimmunity and Cancer1
Barbara J. Vilen (78), Molecular Immunology, Signal Transduction, and B Cell Tolerance
Jason Whitmire, Viral Immunology, Memory T-Cell Differentiation, Vaccines, Inflammation, Microbial ImmunologyJason Whitmire, Viral Immunology, Memory T-Cell Differentiation, Vaccines, Inflammation, Microbial Immunology1
Matthew C. Wolfgang (89), Microbial Pathogenesis, Bacterial Gene Regulation, Host-Pathogen Interactions
Yisong Wan (103), Regulatory T-Cell and TGF-Beta Signaling Controlled T-Cell Function under Normal and Pathological Conditions

Assistant Professors

Janelle Arthur, Microbiota, Inflammation and Innate Immunity, Colorectal Cancer
Brian Conlon, Antibiotic resistance, Bacteriology
Nilu Goonetilleke, T-Cell Immunology, HIV-1 Immunobiology
Jonathan Hansen (110), Pathogenesis of Crohn's Disease and Ulcerative Colitis, Host-Commensal Interactions1
Matthew Hirsch, AAV Gene Therapy, Gene Editing, Cellular Response to Foreign DNA1
Helen Lazear, Innate Immune Mechanisms That Control Flavivirus Pathogenesis
Edward Miao (107), Innate Immune Detection of Microbial Virulence
Cary Moody (103), Pathogenesis of Human Papillomaviruses
Nathaniel Moorman (104), Molecular Virology, Host Pathogen Interactions, HCMV Pathogenesis
Uma Nagarajan, Innate Immune Response to Chlamydia Infection and Its Role in Pathogenesis
Elizabeth Shank (111), Microbial Interactions1
Rita Tamayo (100), Microbial Pathogenesis, Bacterial Genetics, Bacterial Gene Regulation

Research Professors

Nancy C. Fisher, Flow Cytometry
Marcia M. Hobbs, Pathogenesis of Nonviral Sexually Transmitted Infections (Trichomonas vaginalis, Neisseria gonorrhoeae) and Molecular Diagnostics1

Research Associate Professors

Julie A.E. Nelson, Molecular Virology, HIV Evolution and Pathogenesis, HCV Co-Infection, HIV Assay Development and HIV Clinical Trial Virology
Ruth Silversmith, Bacterial Chemotaxis, Mechanisms of Phosphotransfer Reactions
Bo Wang, Autoimmune Pathogenesis and Immunotherapy of Type 1 Diabetes

Research Assistant Professors

W. June Brickey, Host Immune Responses, Radiation Injury, Expression Profiling
Sarah Joseph
Robert Maile, Cellular Immunology, Burn Immunology, Transplantation, T-Cell Regulation, Bacterial and Viral Infectivity1
Karen McKinnon, Dendritic Cell Induction of Tumor Specific CD4 and CD8 T Lymphocytes
Sang-Hoon Sin, Mouse Models of Viral Lymphoma
Kimberly Walker, Microbial Pathogenesis, Bacterial Gene Regulation
Christopher Whitehurst, Epstein-Barr Virus, Ubiquitination/Deubiqutination Processes

Adjunct Professor

Steven L. Bachenheimer
Stephen H. Clarke

Adjunct Associate Professor

Anthony Richardson

Adjunct Assistant Professor

Jennifer Martinez

Professors Emeriti

Steven L. Bachenheimer
Kenneth F. Bott
Janne G. Cannon
Marshall H. Edgell
Susan A. Fiscus
Jeffrey A. Frelinger
Harry Gooder
Jean Handy
Eng Shang Huang
Clyde A. Hutchison III
Robert E. Johnston
David G. Klapper
John E. Newbold
Nancy Raab-Traub
John H. Schwab
P. Frederick Sparling1
Robert Twarog

1

joint faculty members

MCRO

Advanced Undergraduate and Graduate-level Courses

MCRO 449. Introduction to Immunology. 3 Credits.

This course provides a general overview of the evolution, organization, and function of the immune system. Instruction will be inquiry-based with extensive use of informational and instructional technology tools.
Requisites: Prerequisite, BIOL 205; permission of the instructor for students lacking the prerequisite.
Grading status: Letter grade
Same as: BIOL 449.

MCRO 515. Introduction to Microbiology. 4 Credits.

Open only to dental students. A course covering basic aspects of microbiology and immunology including sterilization, action of antimicrobial chemotherapeutic agents, concepts of infection and immunity, and the study of certain selected infectious agents.
Grading status: Letter grade.

MCRO 614. Immunobiology. 3 Credits.

A strong background in molecular biology, eukaryotic genetics, and biochemistry is required. Advanced survey course with topics that include molecular recognition, genetic mechanisms of host resistance, development of cells and cell interactions; hypersensitivity, autoimmunity, and resistance to infection. Course material from textbook and primary literature.
Grading status: Letter grade.

MCRO 630. Virology. 3 Credits.

Required preparation, coursework in molecular biology and cell biology. Current concepts of the chemistry, structure, replication, genetics, and the natural history of animal viruses and their host cells.
Grading status: Letter grade.

MCRO 631. Advanced Molecular Biology I. 3 Credits.

Required preparation for undergraduates, at least one undergraduate course in both biochemistry and genetics. DNA structure, function, and interactions in prokaryotic and eukaryotic systems, including chromosome structure, replication, recombination, repair, and genome fluidity. Three lecture hours a week.
Grading status: Letter grade
Same as: GNET 631, BIOC 631, BIOL 631.

MCRO 632. Advanced Molecular Biology II. 3 Credits.

Required preparation for undergraduates, at least one undergraduate course in both biochemistry and genetics. The purpose of this course is to provide historical, basic, and current information about the flow and regulation of genetic information from DNA to RNA in a variety of biological systems. Three lecture hours a week.
Grading status: Letter grade
Same as: GNET 632, BIOC 632, BIOL 632.

MCRO 635. Microbial Pathogenesis I. 3 Credits.

Permission of the instructor. Required preparation, coursework in molecular biology and genetics. Topics will include aspects of basic bacteriology as well as bacterial and fungal pathogens and mechanisms of disease.
Grading status: Letter grade.

MCRO 640. Microbial Pathogenesis II. 3 Credits.

Permission of the instructor or a fundamental understanding of molecular virology and immunology. Molecular pathogenesis, with a primary focus on viral pathogens. Additional topics include vaccines and genetics of host-pathogen interactions.
Grading status: Letter grade.

MCRO 643. Cell Structure, Function, and Growth Control I. 3 Credits.

Comprehensive introduction to cell structure, function, and transformation.
Requisites: Prerequisite, undergraduate cell biology or biochemistry or permission of the instructor.
Grading status: Letter grade
Same as: CBIO 643, BIOC 643, PHCO 643, PHYI 643.

MCRO 644. Cell Structure, Function, and Growth Control II. 3 Credits.

Comprehensive introduction to cell structure, function, and transformation.
Requisites: Prerequisite, undergraduate cell biology or biochemistry or permission of the instructor.
Grading status: Letter grade
Same as: CBIO 644, PHCO 644, BIOC 644, PHYI 644.

MCRO 690. Special Topics in Microbiology or Immunology. 1-15 Credits.

Permission of the department except for department majors. Designed to introduce the student to research methods. Minor investigative problems are conducted with advice and guidance of the staff. Hours and credit to be arranged, any term. May be repeated for credit two or more semesters.
Repeat rules: May be repeated for credit; may be repeated in the same term for different topics; 15 total credits. 5 total completions.
Grading status: Letter grade.

Graduate-level Courses

MCRO 701. Seminar in Microbiology and Immunology. 1 Credit.

Faculty and student seminars on current research in microbiology and immunology.
Repeat rules: May be repeated for credit.

MCRO 702. Seminar in Microbiology. 1 Credit.

Seminar on selected topics in microbiology.
Repeat rules: May be repeated for credit.

MCRO 710. Seminar/Tutorial in Prokaryotic Molecular Biology. 1-15 Credits.

One or two faculty and a small number of students will consider current research of importance in depth. Emphasis is on current literature, invited speakers, etc., rather than textbooks.
Repeat rules: May be repeated for credit. 15 total credits. 99 total completions.

MCRO 711. Seminar/Tutorial in Animal Virology. 1-15 Credits.

One or two faculty and a small number of students consider current research of importance in depth. Emphasis is on current literature, invited speakers, etc., rather than textbooks.
Repeat rules: May be repeated for credit. 15 total credits. 99 total completions.

MCRO 712. Seminar/Tutorial in Immunology. 1-15 Credits.

One or two faculty and a small number of students consider current research of importance in depth. Emphasis is on current literature, invited speakers, etc., rather than textbooks.
Repeat rules: May be repeated for credit.

MCRO 790. Directed Readings in Prokaryotic Molecular Biology. 1 Credit.

Permission of the instructor or one prior prokaryotic molecular biology course. Directed readings in prokaryotic molecular biology under the direction of a member of the graduate faculty. May be repeated for credit.
Repeat rules: May be repeated for credit.

MCRO 791. Directed Readings in Virology. 1 Credit.

Permission of the instructor or one prior virology course. Directed readings in virology under the direction of a member of the graduate faculty. May be repeated for credit.
Repeat rules: May be repeated for credit.

MCRO 792. Directed Readings in Immunology. 1 Credit.

Permission of the instructor or one prior immunology course. Directed readings in immunology under the direction of a member of the graduate faculty. May be repeated for credit.
Repeat rules: May be repeated for credit.

MCRO 795. Research Concepts. 2 Credits.

Permission of the instructor. This course will provide multiple opportunities for the student to write parts of hypothesis-based proposals, receive substantial feedback, and to rewrite the text. There will be approximately twelve single-page writing assignments.

MCRO 901. Research in Microbiology or Immunology. 1-15 Credits.

Permission of the department. Designed to introduce the student to research methods and special techniques. Short-term problems are conducted with the advice and guidance of the staff. May be repeated for credit.
Repeat rules: May be repeated for credit.

MCRO 993. Master's Research and Thesis. 3 Credits.

MCRO 994. Doctoral Research and Dissertation. 3 Credits.