BIOMEDICAL ENGINEERING (BMME)

BMME 89. First Year Seminar: Special Topics. 3 Credits.

Special topics course. Content will vary each semester.
Repeat rules: May be repeated for credit; may be repeated in the same term for different topics; 6 total credits. 2 total completions.
Grading status: Letter grade.

BMME 101. Frontiers of Biomedical Engineering. 1 Credit.

An introduction to the groundbreaking tools and topics of biomedical engineering, including medical imaging, medical robotics, rehabilitative engineering, regenerative medicine, and medical device design.
Grading status: Letter grade.

BMME 150. Introduction to Materials Science. 3 Credits.

Focus on the materials science and processing of electronic, metallic, polymeric, ceramic, and composite materials. The electronic, optical, magnetic, and structural properties of materials are related to their applications.
Requisites: Prerequisite, CHEM 102; co-requisites, MATH 383 and PHYS 117 or 119.
Grading status: Letter grade.

BMME 160. Statics. 3 Credits.

Course covers rigid body mechanics of bodies at equilibrium or at rest (statics), and an introduction to rigid body mechanics of bodies in motion (dynamics). A foundation in engineering concepts and practices required to design and analyze many types of structural members is presented. Provides a foundation for more advanced courses.
Requisites: Prerequisites, MATH 232, and PHYS 116 or 118.
Grading status: Letter grade.

BMME 190. Special Topics in Biomedical Engineering. 1-3 Credits.

A study in the special fields under the direction of the faculty. Offered as needed for presenting material not normally available in regular BMME courses.
Repeat rules: May be repeated for credit; may be repeated in the same term for different topics; 9 total credits. 3 total completions.
Grading status: Letter grade.

BMME 201. MATLAB for Scientists and Engineers. 3 Credits.

This course introduces students to problem-solving techniques using the MATLAB programming language. Fundamental computer science basics are taught as they relate to problems encountered in biomedical engineering and other scientific disciplines. Programming activities will incorporate actual data (e.g., stress/strain data and microscopy images) for relevant, real-world examples.
Requisites: Prerequisites, MATH 231; corequisite, MATH 232.
Grading status: Letter grade.

BMME 210. BME Design and Manufacturing I. 2 Credits.

Students will learn: use of design software (SolidWorks and support/analysis programs); basic techniques for directly measuring solid objects; electronic assembly techniques; and how to design simple electronic circuits. Note: BME Toolkit purchase is required for this course.
Requisites: Co-requisite, PHYS 117 or 119.
Grading status: Letter grade.

BMME 310. BME Design and Manufacturing II. 2 Credits.

Students learn basic tools and procedures of modern design and practice traditional and modern rapid manufacturing technologies/techniques. Laboratory exercises and Web-based instructional content.
Requisites: Prerequisite, BMME 210.
Grading status: Letter grade.

BMME 341. Thermodynamics and Kinetics Applied to Solids. 3 Credits.

The elements of thermodynamics and phenomenological kinetics of diffusion appropriate to solids are examined. Topics include equations of state, heat capacity, polyphase equilibria, phase transitions, diffusion, and interfaces.
Requisites: Prerequisites, BMME 150, MATH 383, and PHYS 117.
Grading status: Letter grade.

BMME 350. Electronics for Biomedical Engineers. 4 Credits.

Fundamentals of analog and digital circuit analysis and design as applied to biomedical instrumentation and measurement of biological potentials. Class will consist of lectures and problem solving of analog and digital circuits. In lab students will design, develop, and test circuits, and acquire data to a computer using LabView.
Requisites: Prerequisite, PHYS 117 or 119.
Grading status: Letter grade.

BMME 351. Human Physiology and Biological Measurements for Engineers. 4 Credits.

A course on the quantitative aspects of basic human physiology. Class work will provide students with a basic understanding of human anatomy and physiology. A laboratory portion will explore actual physiological measurement techniques and quantitatively evaluate human physiology using statistical analyses.
Requisites: Prerequisite, BMME 350; co-requisite, BIOL 252.
Grading status: Letter grade.

BMME 395. Research in Biomedical Engineering for Undergraduates. 1-4 Credits.

Permission of the director of undergraduate studies. At least nine hours of independent work a week. Research with a faculty mentor. Approved learning contract required. Research proposal and final research paper also required.
Gen Ed: EE-Mentored Research.
Repeat rules: May be repeated for credit. 12 total credits. 4 total completions.
Grading status: Letter grade.

BMME 396. Independent Study in Biomedical Engineering. 1-3 Credits.

Permission of the director of undergraduate studies. Independent study under a member of the biomedical engineering faculty. Approved learning contract required.
Repeat rules: May be repeated for credit. 12 total credits. 4 total completions.
Grading status: Letter grade.

BMME 405. Biomechanics I. 3 Credits.

This course provides an overview of musculoskeletal anatomy, and of the mechanical behavior of biological tissues and biological systems. Students learn to apply fundamental principles of mechanics to analyze movement in humans and other animals. Applications in rehabilitation and orthopedics are emphasized.
Requisites: Prerequisites, MATH 383, and PHYS 116 or 118.
Grading status: Letter grade.

BMME 410. Systems and Signals. 3 Credits.

Analysis of linear systems by transform methods to networks, including Fourier transforms, Laplace transforms, and convolution. Survey of linear systems applications to biomedical problems.
Requisites: Prerequisite, MATH 383; co-requisite, MATH 528.
Grading status: Letter grade.

BMME 420. Introduction to Synthetic Biology. 3 Credits.

This course provides an introduction to the ideas and methodologies in the field of synthetic biology. Lectures focus on fundamental concepts in molecular biology and engineering as applied to biological system design. The laboratory portion of the course provides hands-on application of fundamental techniques in synthetic biology research.
Requisites: Prerequisites, BIOL 101 and CHEM 101; corequisite, BIOL 202 and CHEM 102.
Grading status: Letter grade.

BMME 425. Biomedical Applications of Electromagnetics. 3 Credits.

This course is designed to introduce diagnostic and therapeutic applications of electrostatic, magnetostatic, quasi-static, and radio-frequency electromagnetic fields. Students are expected to gain a better understanding of the physics behind electromagnetic interactions with biological tissues, and become familiar with numerical skills and hardware fundamentals for bio-electromagnetic devices.
Requisites: Prerequisites, MATH 383, COMP 116 or BMME 201, and PHYS 117 or 119.
Grading status: Letter grade.

BMME 435. Biological Physics. 3 Credits.

How diffusion, entropy, electrostatics, and hydrophobicity generate order and force in biology. Topics include DNA manipulation, intracellular transport, cell division, molecular motors, single molecule biophysics techniques, nerve impulses, neuroscience.
Requisites: Prerequisites, PHYS 116 and 117, or PHYS 118 and 119.
Grading status: Letter grade
Same as: PHYS 405, BIOL 431.

BMME 445. Systems Neuroscience. 3 Credits.

Introduction to methodologies used to characterize a) the aggregate behavior of living neural networks and b) the changes in that behavior that occur as a function of stimulus properties, pharmacological manipulations, and other factors that dynamically modify the functional status of the network.
Requisites: Prerequisite, BIOL 252.
Grading status: Letter grade.

BMME 455. Biofluid Mechanics. 3 Credits.

This course introduces students to basics of fluid mechanics (steady and pulsatile flows, laminar and turbulent flows, and Newtonian and non-Newtonian flows). Students learn the fundamental relationships and governing equations describing these types of flows and the basic physiology of certain systems that are highly associated with fluid flows.
Requisites: Prerequisites, BMME 160, MATH 528, and BMME 201 or COMP 116.
Grading status: Letter grade.

BMME 460. Analytical Microscopy. 3 Credits.

The purpose of this course is to present microscopy techniques utilized in the analysis of biological and chemical samples. This course provides a systematic and in-depth examination of light and electron microscopy, including their various components, for example, detectors, light sources, and lenses. For graduate students and advanced undergraduates.
Grading status: Letter grade.

BMME 465. Biomedical Instrumentation I. 4 Credits.

Topics include basic electronic circuit design, analysis of medical instrumentation circuits, physiologic transducers (pressure, flow, bioelectric, temperate, and displacement). This course includes a laboratory where the student builds biomedical devices. Note, an embedded computer kit purchase is required for this course.
Requisites: Prerequisites, BMME 350, and COMP 116 or BMME 201.
Grading status: Letter grade.

BMME 470. Tissue Engineering. 3 Credits.

Lectures in this course address how to quantitatively evaluate functional engineered tissues. The course provides an overview of the field, with emphasis on detailed evaluation of scientific and commercial progress over time, and design principles that must be met to develop a process or fabricate a functional tissue-engineered part.
Requisites: Prerequisites, BIOL 252 and BMME 351.
Grading status: Letter grade.

BMME 475. Transport Processes. 3 Credits.

This course serves as introduction for engineers pursuing transport phenomena and for future pharmaco-engineers requiring predictive models of mass transfer or pharmacodynamic models. Material is designed to address heat and mass transfer issues in nanotechnology, microfabrication, mems, cell therapies, bioartificial organs, as well as pharmacodynamic modeling of dynamic "omics" datasets.
Grading status: Letter grade.

BMME 485. Biotechnology. 3 Credits.

This course is designed to prepare a biomedical engineering student with the survey tools to understand key components in modern biotechnologies. Fundamental concepts, theory, design, operation, and analysis of the most common biotechnologies in bioengineering will be presented.
Requisites: Prerequisites, BIOL 101 and 101L, CHEM 102 and 102L, and PHYS 117 or 119.
Grading status: Letter grade.

BMME 490. Special Topics in Biomedical Engineering. 3-9 Credits.

A study in the special fields under the direction of the faculty. Offered as needed for presenting material not normally available in regular BMME courses.
Repeat rules: May be repeated for credit; may be repeated in the same term for different topics; 12 total credits. 4 total completions.
Grading status: Letter grade.

BMME 495. Undergraduate Research in Biomedical Engineering as a Technical Elective. 3 Credits.

Opportunity for hands-on faculty mentored research project in biomedical engineering. Approved plan of work required with significant independent research culminating in a final paper and presentation at an appropriate venue. Departmental approval required. Course may not be repeated.
Grading status: Letter grade.

BMME 505. Biomechanics II. 3 Credits.

A firm understanding of the principles of mechanics is an important foundation to biomechanics. This course builds upon what was learned in BMME 405 by providing a deep understanding of the mechanics of materials with applications to the strength of the bone, implant analysis, and testing of biological materials.
Requisites: Prerequisites, MATH 383, BMME 160 and 405.
Grading status: Letter grade.

BMME 510. Biomaterials. 3 Credits.

Focus on the mechanical, chemical, and biocompatibility considerations of any material (e.g., metal, ceramic, or polymer) designed to interface with the body. Various applications of biomaterials are presented and analyzed, including femoral implants and vascular grafts, in order to guide students in a semester-long design project.
Requisites: Prerequisites, BIOL 101 and BMME 150.
Grading status: Letter grade.

BMME 515. Introduction to Systems Biology. 3 Credits.

Cells, tissues, organs, and organisms have been shaped through evolutionary processes to perform their functions in robust, reliable manners. This course investigates design principles and structure-function relationships of biomolecular networks. Emphasis will be placed on gene- and protein-circuits and their role in controlling cellular behavior and phenotype.
Requisites: Prerequisite, MATH 383 or 528.
Grading status: Letter grade.

BMME 520. Fundamentals of Materials Engineering. 3 Credits.

The structure, defects, thermodynamics, kinetics, and properties (mechanical, electrical, thermal, and magnetic) of matter (metals, ceramics, polymers, and composites) will be considered.
Grading status: Letter grade.

BMME 530. Digital Signal Processing I. 3 Credits.

This is an introduction to methods of automatic computation of specific relevance to biomedical problems. Sampling theory, analog-to-digital conversion, digital filtering will be explored in depth.
Requisites: Prerequisite, COMP 110 or 116.
Grading status: Letter grade.

BMME 550. Medical Imaging I: Ultrasonic, Optical, and Magnetic Resonance Systems. 3 Credits.

Physical and mathematical foundations of ultrasonic, optical, and magnetic resonance imaging systems in application to medical diagnostics. Each imaging modality is examined, highlighting critical system characteristics: underlying physics of the imaging system, including mechanisms of data generation and acquisition; image creation; and relevant image processing methods, such as noise reduction.
Requisites: Prerequisites, BIOS 550, BMME 530, and PHYS 128.
Grading status: Letter grade.

BMME 551. Medical Device Design I. 3 Credits.

Student multidisciplinary teams work with local medical professionals to define specific medical device concepts for implementation.
Grading status: Letter grade.

BMME 552. Medical Device Design II. 3 Credits.

Device prototypes designed in the first course in series. Good manufacturing practices; process validation; FDA quality system regulations; design verification and validation; regulatory approval planning; and intellectual property protection.
Grading status: Letter grade.

BMME 560. Medical Imaging II: X-Ray, CT, and Nuclear Medicine Systems. 3 Credits.

Overview of medical imaging systems using ionizing radiation. Interaction of radiation with matter. Radiation production and detection. Radiography systems and applications. Tomography. PET and SPECT systems and applications.
Requisites: Prerequisites, BIOS 550, BMME 410, and PHYS 128.
Grading status: Letter grade.

BMME 565. Biomedical Instrumentation I. 4 Credits.

Topics include basic electronic circuit design, analysis of medical instrumentation circuits, physiologic transducers (pressure, flow, bioelectric, temperate, and displacement). This course includes a laboratory where the student builds biomedical devices.
Requisites: Prerequisite, PHYS 351.
Grading status: Letter grade.

BMME 576. Mathematics for Image Computing. 3 Credits.

Mathematics relevant to image processing and analysis using real image computing objectives and provided by computer implementations.
Requisites: Prerequisites, COMP 116 or 401, and MATH 233.
Grading status: Letter grade
Same as: COMP 576.

BMME 580. Microcontroller Applications I. 3 Credits.

Introduction to digital computers for real-time processing and control of signals and systems. Programming input and output devices using C and assembly language is stressed. Case studies are used to present software design strategies for real-time laboratory systems.
Requisites: Prerequisites, BIOL 252, BMME 350, and COMP 116 or BMME 201; co-requisite, BMME 351.
Grading status: Letter grade.

BMME 581. Microcontroller Applications II. 3 Credits.

Problems of interfacing computers with biomedical systems are studied. Students collaborate to develop a new biomedical instrument. Projects have included process control, data acquisition, disk systems interfaces, and DMW interfaces between interconnected computers.
Requisites: Prerequisites, BMME 465 and 580.
Grading status: Letter grade.

BMME 681. Human Factors Engineering and Quality Management Systems for Engineers. 3 Credits.

This course teaches human factors engineering, risk assessment, and quality management systems. At the end of the course, students will be able to apply their knowledge to their senior design project and test for a six sigma green belt certification.
Grading status: Letter grade.

BMME 691H. Honors Thesis. 3 Credits.

Research honors course. Prior approval needed from the chair or associate chair of the program for topic selection and faculty research mentor. Minimum GPA requirement, written report, and abstract requirements as set forth by the honors program.
Gen Ed: EE-Mentored Research.
Grading status: Letter grade.

BMME 692H. Honors Thesis. 3 Credits.

Research honors thesis continuation with required GPA, research topic selection with approved faculty mentor. Written abstract and report per honors program guidelines submitted by specific deadlines.
Gen Ed: EE-Mentored Research.
Grading status: Letter grade.

BMME 697. Senior Design Project I. 3 Credits.

Conceptual prelude and preparation to BMME 698, in which the theoretical and practical knowledge acquired during the undergraduate tenure is applied to develop a solution to a real-world problem.
Requisites: Prerequisite, BMME 310.
Grading status: Letter grade.

BMME 698. Senior Design Project II. 3 Credits.

Implementation phase of the senior design experience. Students apply the theoretical and practical knowledge they have acquired in their previous seven semesters to the design and implementation of a solution to a real-world problem.
Requisites: Prerequisite, BMME 697.
Gen Ed: CI, EE-Mentored Research.
Grading status: Letter grade.

BMME 740. Advanced Biomaterials. 3 Credits.

Medical or dental implants or explants are highlighted from textbooks, scientific literature, and personal accounts.
Requisites: Prerequisite, BMME 510; Permission of the instructor for students lacking the prerequisite.
Same as: MTSC 740.

BMME 770. Physiology and Methods in Genomics. 4 Credits.

Lectures in physiology systems and lab techniques covering various functional genomic methods including DNA sequencing, gene arrays, proteomics, confocal microscopy, and imaging modalities.

BMME 775. Image Processing and Analysis. 3 Credits.

Approaches to analysis of digital images. Scale geometry, statistical pattern recognition, optimization. Segmentation, registration, shape analysis. Applications, software tools.
Requisites: Prerequisites, COMP 665, MATH 547, and STOR 435.
Same as: COMP 775.

BMME 790. Graduate Systems Physiology. 3 Credits.

This is the second semester of the two-semester series intended to provide graduate students with an introduction to systems and organ physiology.
Requisites: Prerequisite, BMME 589.

BMME 795. Information Processing in the Central Nervous System. 3 Credits.

Introduction to methodologies used to characterize a) the aggregate behavior of living neural networks and b) the changes in that behavior that occurs as a function of stimulus properties, pharmacological manipulations, and other factors that dynamically modify the functional status of the network.
Requisites: Prerequisite, BMME 589.

BMME 810. Digital Nuclear Imaging. 3 Credits.

Advanced topics of physics and instrumentation in nuclear imaging and magnetic resonance techniques.
Requisites: Prerequisites, BMME 550 and 560.

BMME 840. Rehabilitation Engineering Design. 4 Credits.

Students will design an assistive technology device to help individuals with disabilities to become more independent. The project will be used in the community when it is completed.
Requisites: Prerequisite, BMME 465; Permission of the instructor for students lacking the prerequisite.

BMME 890. Special Topics. 1-21 Credits.

Permission of the instructor. Special library and/or laboratory work on an individual basis on specific problems in biomedical engineering and biomedical mathematics. Direction of students is on a tutorial basis and subject matter is selected on the basis of individual needs and interests.
Repeat rules: May be repeated for credit; may be repeated in the same term for different topics.

BMME 900. Research in Biomedical Engineering and Biomathematics. 1-21 Credits.

Permission of the instructor.

BMME 993. Master's Research and Thesis. 3 Credits.

BMME 994. Doctoral Research and Dissertation. 3 Credits.