CELL BIOLOGY AND PHYSIOLOGY (CBPH)

CBPH 701. Physiology Laboratory Rotation. 1-6 Credits.

Permission of the director of graduate studies. Rotations in faculty laboratories introduce methods and techniques in physiology. Individual projects provide an opportunity to explore potential dissertation topics.

CBPH 702. Experimental Physiology of Human Health and Disease. 4 Credits.

Principles of cell, organ, and systems physiology and pathophysiology required to identify important areas of biomedical research, using model systems, common disease examples (schizophrenia, hypertension, diabetes), and current research opportunities.

CBPH 703. Experimental Physiology of Human Health and Disease. 4 Credits.

Permission of the instructor. Molecular and cellular basis of organ system function; integration of systems to maintain the normal state. Understanding of normal physiology is amplified by examples from human disease and mouse models. Principles of cell, organ, and integrative physiology and how these principles apply to translational research.

CBPH 705. Communicating Scientific Results. 1 Credit.

Practice in oral and written communication evaluated by peers and faculty. Includes delivery of coached presentations on topics in physiology and preparation of writing assignments typically encountered in scientific life.
Repeat rules: May be repeated for credit.

CBPH 706. Communicating Scientific Results. 1 Credit.

Practice in oral and written communication evaluated by peers and faculty. Includes delivery of coached presentations on topics in physiology and preparation of writing assignments typically encountered in scientific life.
Repeat rules: May be repeated for credit.

CBPH 710. Medical Neurobiology. 1-3 Credits.

Permission of the instructor. A special section (for physiology graduate students only) of the neurobiology course for medical students. Structural and functional organization is analyzed at the level of the cell membrane, the neuron, and integrated neuronal systems.
Same as: NBIO 710.

CBPH 712A. Special Topics in Physiology. 1-5 Credits.

Permission of the instructor. Individually arranged in-depth programs of study of selected topics such as membrane function, transport physiology, renal physiology, etc.
Same as: NBIO 891.

CBPH 712B. Special Topics in Physiology. 1-5 Credits.

Permission of the instructor. Individually arranged in-depth programs of selected topics such as membrane function, transport physiology, renal physiology, etc.
Same as: NBIO 892.

CBPH 712C. Organ System Physiology in Health and Disease: Respiratory Physiology. 1 Credit.

The course begins with the basic physiology of respiration and gas transport, then applies that understanding to in-depth discussions of common respiratory diseases. Format is lecture plus journal club.

CBPH 714. Physiology. 4 Credits.

This basic physiology course introduces students to the functions of and interactions between the various systems of the body. Particular emphasis is placed on those concepts of specific relevance for students and practitioners of dentistry. The course also provides students with a solid physiological background for subsequent courses within the dentistry curriculum.
Same as: DENT 114.

CBPH 720. Human Physiology. 1-5 Credits.

Permission of the instructor. A special section (for physiology graduate students only) of the course for medical students. The course provides a general consideration of cell function and systemic physiology. Six lecture hours per week.

CBPH 721. Stem Cells and Maturational Lineage Biology. 4 Credits.

All tissues are organized with stem cell compartments giving rise to maturational cell lines with lineage-dependent phenotypic characteristics. Investigators discuss research in stem cell biology and regenerative medicine.
Requisites: Prerequisites, BIOL 111; CHEM 101, 102, and 241.

CBPH 722. Cellular and Molecular Neurobiology I. 2-6 Credits.

Lecture/discussion course on the physiology, pharmacology, biochemistry, and molecular biology of the nervous system. Topics include function and structure of ion channels, neurotransmitter biosynthesis and release mechanisms, neurotransmitter receptors, and intracellular signaling pathways.
Same as: PHCO 722.

CBPH 722A. Cellular and Molecular Neurobiology: Introduction and Electrical Signaling. 2 Credits.

Permission of the department. Introduces topics as brain cell biology, molecular biology applied to neurons, membrane potentials and imaging methods. The second half of this block introduces such topics as resistance, capacitance, passive membranes, classes of ion channels, potassium and calcium channels, and action potential initiation.
Same as: NBIO 722A, BIOC 722A, PHCO 722A.

CBPH 722B. Cellular and Molecular Neurobiology: Postsynaptic Mechanisms-Receptors. 2 Credits.

Permission of the department. Consideration of membrane receptor molecules activated by neurotransmitters in the nervous system with emphasis on ligand binding behavior and molecular and functional properties of different classes of receptors. Course meets for four weeks with six lecture hours per week.
Same as: NBIO 722B, BIOC 722B, PHCO 722B.

CBPH 722C. Cellular and Molecular Neurobiology: Synaptic Transmissions. 2 Credits.

Permission of the department. This block focuses on neurotransmitter signaling through distinct receptor subclasses. Topics include G-protein coupled receptors and associated signaling, receptor binding theory, ionotropic and metabotropic glutamate and GABA receptors, receptor trafficking and localization. Course meets for five weeks with six lecture hours per week.
Same as: NBIO 722C, BIOC 722C, PHCO 722C.

CBPH 723. Cellular and Molecular Neurobiology II. 2-6 Credits.

Lecture/discussion course on the physiology, pharmacology, biochemistry, and molecular biology of the nervous system. Topics include function and structure of ion channels, neurotransmitter biosynthesis and release mechanisms, neurotransmitter receptors and intracellular signaling pathways.
Same as: PHCO 723.

CBPH 723A. Cellular and Molecular Neurobiology: Development of the Nervous System. 2 Credits.

Permission of the department. This block covers neural induction, neural stem cells, glial development, neural cell death and neurotrophin during development, and synaptic adhesion molecules.
Same as: NBIO 723A, BIOC 723A, PHCO 723A.

CBPH 723B. Cellular and Molecular Neurobiology: Anatomy and Function of Sensory and Motor Systems. 2 Credits.

Permission of the department. This block introduces the sensory pathways of vision, audition, taste, olfaction, pain, and touch, as well as the motor pathways of the spinal cord, basal ganglia, cerebellum, and motor cortex. Discusses mechanisms of sensory information processing and motor execution. Includes peripheral and central mechanisms of pain.
Same as: NBIO 723B, BIOC 723B, PHCO 723B.

CBPH 724. Developmental Neurobiology. 2 Credits.

A survey of nervous system development emphasizing detailed analysis of selected research topics such as neuronal induction, neural crest development, neuronal differentiation, synapse formation, neurotrophic factors, glial development, and the effects of experience.
Requisites: Prerequisite, NBIO 722; Permission of the instructor for students lacking the prerequisite.
Same as: NBIO 724.

CBPH 741. Introduction to Human Anatomy. 3 Credits.

A general course for persons preparing for careers as dental hygienists. Two lectures and two laboratory hours a week.

CBPH 751. Seminar in Physiology. 1 Credit.

Permission of the director of graduate studies.

CBPH 752. Seminar in Physiology. 1 Credit.

Permission of the director of graduate studies.

CBPH 791. Gross Anatomy for Physical Therapists. 4 Credits.

Fundamental principles and concepts of human gross anatomy for physical therapists taught by lectures and cadaver dissection. Emphasis on functional anatomy. Three lecture hours and six laboratory hours a week.
Requisites: Prerequisites, BIOL 276 and 276L; Permission of the instructor for students lacking the prerequisites.

CBPH 793. Functional Neuroanatomy. 3 Credits.

Study of basic structure of the brain and spinal cord, including both lecture and laboratory. Primarily for physical therapy students. Four hours a week.
Requisites: Prerequisites, CBIO 607 and 791; permission of the instructor for students lacking the prerequisites.

CBPH 800. Teaching Physiology. 1-3 Credits.

Permission of the instructor. Introduces the principles of teaching physiology. Provides students the opportunity to plan instruction and to teach with increasing degrees of responsibility. The teaching internship is under the direct supervision of a faculty mentor.

CBPH 805. Gross Anatomy. 4 Credits.

Systematic approach to gross anatomy emphasizing a regional approach stressing head and neck anatomy. Primarily for dental students.

CBPH 832. Respiratory Physiology: Defense Mechanisms in the Airways. 1-4 Credits.

The integrated defense mechanisms that protect the airways and lung from inhaled allergens, irritants, particulates, and pathogens. Topics include transepithelial ion transport, mucociliary clearance, and innate immune responses.
Requisites: Prerequisite, PHYI 703.

CBPH 833. Gastrointestinal Physiology: Growth, Cancer, Inflammation, and the Microbiome. 1-3 Credits.

Roles of growth factor and cytokine signaling, and the intestinal microbiome in normal intestinal growth, inflammation, or colon cancer. Molecular, cellular, genomic, model organisms and translational medicine approaches.
Requisites: Prerequisite, PHYI 703.

CBPH 834. Pain and Somatic Sensation. 1-15 Credits.

Consideration of peripheral and central neural mechanisms for somatic sensation with particular emphasis on pain.
Requisites: Prerequisite, PHYI 720; Permission of the instructor for students lacking the prerequisite.

CBPH 835. CNS Organization. 1 Credit.

Primary literature explores how the nervous system is organized, integrates information, and adapts.

CBPH 836. Excitable Membranes, Receptors, Channels and Synapses. 1-4 Credits.

Basic neurophysiology of excitable membranes, channels, and synapse as the basis of neuronal communication.

CBPH 839. Endothelial Cells in Health and Disease. 1 Credit.

Literature-based survey of endothelial cell biology including development, angiogenesis, environmental influences, and disease models.
Requisites: Prerequisite, PHYI 703.

CBPH 840. Renal/Cardiovascular Systems. 1-4 Credits.

Blood pressure control in normal, diseased, and genetically modified animals. Physiology and pathophysiology of the renal and cardiovascular systems.
Requisites: Prerequisite, PHYI 703; Permission of the instructor.

CBPH 850. Seminar in Neurobiology. 3 Credits.

Permission of the department. An intensive consideration of selected topics and problems in neurobiology. The course focuses on the development of presentation and evaluation skills of the trainees. Six credit hours required for neurobiology graduates.
Same as: NBIO 850, BIOL 850, PHCO 850.

CBPH 890. Advanced Topics in Cell and Developmental Biology. 1-15 Credits.

Permission of the instructor. Seminar/discussion course dealing with advanced topics in modern cell biology and/or developmental biology. Based mainly on discussion of current literature.

CBPH 891A. Contemporary Problems. 3 Credits.

Permission of the instructor. Analysis of grant proposals dealing with advanced topics in modern cell biology and/or developmental biology.

CBPH 892B. Contemporary Problems. 3 Credits.

Permission of the instructor. Analysis of grant proposals dealing with advanced topics in modern cell biology and/or developmental biology.

CBPH 893. Cell Biology I. 4 Credits.

Permission of the instructor. Graduate students only. Discussion based course that covers key elements of cell, molecular, and developmental biology, and genetics. Students present and discuss breakthrough primary research papers under the direction of faculty members across the department. Minimal instructor lecturing is included.

CBPH 894. Modern Concepts in Cell Biology II. 4 Credits.

Literature based discussion course on experimental approaches in Cell Biology. Emphasis is on small group discussion and dissection of primary literature including methods, scientific logic, and critical thinking. Each session typically includes both a discussion of key background by a faculty member and student led discussions of selected papers from the primary literature.

CBPH 899. Electron Microscopy Principles and Applications. 3 Credits.

Permission of the instructor. Lectures on scanning, transmission, high voltage, freeze fracture, analytical and immunoelectron microscopy. Laboratory training in preparation of biological specimens, operation of scanning and transmission microscopes, and darkroom procedures. Three lecture hours and twelve laboratory hours per week.

CBPH 901. Research in Physiology. 3-10 Credits.

CBPH 902. Research in Physiology. 3-10 Credits.

CBPH 903. Research in Physiology. 3-10 Credits.

CBPH 910. Research. 2-15 Credits.

Credit to be arranged in individual cases.

CBPH 915. Research Laboratory Apprenticeship. 2 Credits.

Enrollment in the cell biology and anatomy graduate program required. A course for first- and second-year graduate students in cell biology and anatomy, consisting of a research project of limited scope pursued under the supervision of a faculty member.
Repeat rules: May be repeated for credit.

CBPH 951. Research in Neurobiology. 3-12 Credits.

Permission of the department. Research in various aspects of neurobiology. Six to 24 hours a week.
Same as: NBIO 951, BIOL 951, PHCO 951.

CBPH 993. Master's Research and Thesis. 3 Credits.

CBPH 994. Doctoral Research and Dissertation. 3 Credits.