NEUROSCIENCE (NBIO)

NBIO 400. Conditioning and Learning. 3 Credits.

A comprehensive survey of the methods, findings, and theories of classical and operant conditioning. Skills necessary to evaluate, integrate, and summarize significant original literature will be developed.
Requisites: Prerequisites, PSYC 101 and 222.
Gen Ed: PL.
Grading status: Letter grade
Same as: PSYC 400.

NBIO 401. Animal Behavior. 3 Credits.

PSYC 270 recommended. Ethological, genetic, and physiological variables will be studied in relation to their behavioral effects.
Requisites: Prerequisites, PSYC 101, and PSYC 222 or BIOL 101.
Gen Ed: PL.
Grading status: Letter grade
Same as: PSYC 401.

NBIO 402. Advanced Biopsychology. 3 Credits.

Elements of neurophysiology, neuroanatomy, and neurochemistry as they apply to the understanding of brain-behavior relationships.
Requisites: Prerequisites, PSYC 101 and 220.
Gen Ed: PX.
Grading status: Letter grade
Same as: PSYC 402.

NBIO 411. Neurobiology Laboratory Apprenticeship. 1-21 Credits.

NBIO 412. Neurobiology Laboratory Apprenticeship. 1-21 Credits.

NBIO 450. Tutorial in Neurobiology. 3 Credits.

NBIO 701A. Brain & Behavior I. 3 Credits.

Graduate standing required. A survey of psychological and biological approaches to the study of sensory and perceptual information processing, with an emphasis on touch and pain.
Same as: PSYC 701.

NBIO 702A. Brain & Behavior II. 3 Credits.

A survey of psychological and biological approaches to the study of basic learning and higher integrative processing.
Same as: PSYC 702.

NBIO 703. Advanced Biological Psychology: Central Nervous System. 3 Credits.

Each fall one special topic will be covered in depth (e.g., neural bases of memory storage, homeostasis, and perception). Format includes lectures and seminar meetings with student presentations.
Requisites: Prerequisite, PSYC 402.
Same as: PSYC 703.

NBIO 704. Applications of Experimental Psychology to Health Research. 3 Credits.

This course provides a critical analysis of interdisciplinary research within experimental psychology, including such topics as psychopharmacology, psychoneuroimmunology, psychophysiology, and animal models of brain/behavior disorders.
Same as: PSYC 704.

NBIO 705. Behavioral Pharmacology. 3 Credits.

Basic principles of pharmacology and behavior analysis are considered in relation to drugs that affect the central nervous system.
Requisites: Prerequisite, PSYC 404; permission of the instructor for students lacking the prerequisite.
Same as: PSYC 705, PHCO 705.

NBIO 708. Seminar in the Biological Foundations of Psychology. 3 Credits.

Permission of the instructor. Limited to graduate students in psychology and neurobiology. Lectures and seminar presentations on a wide range of topics in the area of physiological psychology.
Repeat rules: May be repeated for credit.
Same as: PSYC 708.

NBIO 721. Directed Studies in Oral Biology. 1 Credit.

Topics include extracellular matrices, immunology, inflammation, neurobiology, and pain management.
Same as: OBIO 723.

NBIO 722. Cellular and Molecular Neurobiology. 2-6 Credits.

NBIO 722A. Cellular and Molecular Neurobiology: Introduction and Electrical Signaling. 2 Credits.

Permission of the department. Introduces topics as brain cell biology, molecular biology applied to neurons, membrane potentials and imaging methods. The second half of this block introduces such topics as resistance, capacitance, passive membranes, classes of ion channels, potassium and calcium channels, and action potential initiation.
Same as: BIOC 722A, PHCO 722A.

NBIO 722B. Cellular and Molecular Neurobiology: Postsynaptic Mechanisms-Receptors. 2 Credits.

Permission of the department. Consideration of membrane receptor molecules activated by neurotransmitters in the nervous system with emphasis on ligand binding behavior and molecular and functional properties of different classes of receptors. Course meets for four weeks with six lecture hours per week.
Same as: BIOC 722B, PHCO 722B.

NBIO 722C. Cellular and Molecular Neurobiology: Synaptic Transmissions. 2 Credits.

Permission of the department. This block focuses on neurotransmitter signaling through distinct receptor subclasses. Topics include G-protein coupled receptors and associated signaling, receptor binding theory, ionotropic and metabotropic glutamate and GABA receptors, receptor trafficking and localization. Course meets for five weeks with six lecture hours per week.
Same as: BIOC 722C, PHCO 722C.

NBIO 723A. Cellular and Molecular Neurobiology: Development of the Nervous System. 2 Credits.

Permission of the department. This block covers neural induction, neural stem cells, glial development, neural cell death and neurotrophin during development, and synaptic adhesion molecules.
Same as: BIOC 723A, PHCO 723A.

NBIO 723B. Cellular and Molecular Neurobiology: Anatomy and Function of Sensory and Motor Systems. 2 Credits.

Permission of the department. This block introduces the sensory pathways of vision, audition, taste, olfaction, pain, and touch, as well as the motor pathways of the spinal cord, basal ganglia, cerebellum, and motor cortex. Discusses mechanisms of sensory information processing and motor execution. Includes peripheral and central mechanisms of pain.
Same as: BIOC 723B, PHCO 723B.

NBIO 723C. Cellular and Molecular Neurobiology: Imaging & Disease. 2 Credits.

This block covers CNS imaging, regeneration, and such diseases as Alzheimer's, ALS, Parkinson's, epilepsy, addiction, autism, and schizophrenia.

NBIO 725. Experimental Neurophysiology. 3 Credits.

Permission of the instructor. Six or more laboratory hours a week.

NBIO 727. Translational Seminar in Cognitive and Clinical Neuroscience. 2 Credits.

Introduces new neuroimaging techniques and their application to the study of neural correlates of cognitive and behavioral impairments in brain disorders. Reviews the theories and research methodologies that investigate how brain functions support and give rise to mental operations such as attention, memory, emotions, social cognition in the healthy brain.
Repeat rules: May be repeated for credit.

NBIO 728. Diseases of the Nervous System. 2 Credits.

Explores the basic neurobiology and the clinical aspects of a range of diseases of the nervous system, including ALS, Alzheimer's, autism, schizophrenia, multiple sclerosis, deafness, epilepsy, pain, brain tumors, stroke, Parkinson's, and other neurodegenerative diseases.
Requisites: Prerequisites, NBIO 201, or 222 and 223.

NBIO 729. Sensory Neural Information Processing and Representation. 3 Credits.

Additional required preparation, one year of calculus, familiarity with MATLAB or Python, or permission of the instructor. A discussion/reading seminar covering the fundamentals of nervous system information processing and integration, with examples from sensory systems.
Requisites: Prerequisites, NBIO 722 and 733.

NBIO 731. Microscopy: Principles & Applications. 2 Credits.

This course aims to provide the knowledge one may need to understand the reach of microscopy imaging techniques, to be able to choose the right imaging modality, label the sample, carry out the experiment, analyze data, troubleshoot any pitfalls that may occur, and put together a custom optical setup.

NBIO 732. Biological Concepts. 1.5 Credit.

Overview of structures and biological determinants of conditions and diseases of the oral cavity. Both growth and development and pathophysiology will be introduced in the context of three areas of oral biology: biology of extracellular matrices, host-pathogens interactions, and orofacial neurobiology.
Same as: OBIO 732, PHCO 747.

NBIO 733. Neurocircuits and Behavior Journal Club. 1 Credit.

This is journal club course will meet once per week for 90 minutes to discuss new research papers focused on delineating how neurocircuits function to orchestrate various behavioral states. Papers for discussion will be chosen by the instructor and students, and students will rotate in leading discussions.
Requisites: Prerequisites, NBIO 722 and 723.

NBIO 735. Seminar in Chemical Neurobiology. 2 Credits.

Required preparation, two semesters of biochemistry.

NBIO 750. Neuroanalytics: Programming, Statistics, and Machine Learning for the Analysis of Neuroscience Data. 4 Credits.

Practical/theoretical training in advanced data analysis approaches commonly used in neuroscience research. Course useful with modern data collected in Neuroscience, from sequencing, electrophysiology, imaging, biochemistry, and behavior. The concepts will be taught through programming in python, focusing on illustrating concepts by emphasizing graphical representations of how datasets.
Requisites: Prerequisites, NBIO 722 and 723.

NBIO 800. Gene-Brain-Behavior Interactions in Neurodevelopmental Disorders: Perspectives on Disease Mechanisms. 3 Credits.

This seminar examines the topics of genetics, neuroanatomy, physiology, and behavioral development to provide a broad-based and integrated background to understand the etiology and potential mechanism underlying neurodevelopmental disorders.

NBIO 801. Clinical Syndromes and Neurodevelopmental Disorders. 3 Credits.

This seminar will review the epidemiology, pathogenesis, diagnosis and treatment of neurodevelopmental syndromes and disorders. Topics will range from single gene (e.g. fragile X syndrome and tuberous sclerosis) to complex genetic (e.g., autism, schizophrenia), to environmental disorders with varied phenotypes, pathogenetic mechanisms, and treatments.

NBIO 850. Seminar in Neurobiology. 3 Credits.

Permission of the department. An intensive consideration of selected topics and problems in neurobiology. The course focuses on the development of presentation and evaluation skills of the trainees. Six credit hours required for neurobiology graduates.
Same as: BIOL 850, PHCO 850.

NBIO 857. Seminar in Comparative Animal Behavior. 1-2 Credits.

Permission of the instructor. Advanced seminar in comparative animal behavior. May be repeated for credit.
Repeat rules: May be repeated for credit; may be repeated in the same term for different topics.
Same as: BIOL 857.

NBIO 858. Seminar in Comparative Physiology. 1-2 Credits.

Advanced seminar in comparative physiology.
Requisites: Prerequisite, BIOL 451; permission of the instructor for students lacking the prerequisite.
Repeat rules: May be repeated for credit; may be repeated in the same term for different topics.
Same as: BIOL 858.

NBIO 890. Special Topics in Neurobiology. 1-5 Credits.

Special topics in neurobiology. Content will vary from semester to semester.

NBIO 892. Special Topics in Physiology. 1-5 Credits.

Permission of the instructor. Individually arranged in-depth programs of selected topics such as membrane function, transport physiology, renal physiology, etc.

NBIO 893. Neuroscience Seminar Series. 1 Credit.

Diverse but current topics in all aspects of neuroscience. Relates new techniques and current research of notables in the field of neuroscience. Content focuses on presentations by invited, non-UNC faculty, UNC faculty and mini-series presentations from current Neuroscience students. Topics vary from week to week.

NBIO 951. Research in Neurobiology. 3-12 Credits.

Permission of the department. Research in various aspects of neurobiology. Six to 24 hours a week.
Same as: BIOL 951, PHCO 951.

NBIO 993. Master's Research and Thesis. 3 Credits.

Course is designed to certify that the students have achieved a high level of knowledge competence in clinical and basic neurosciences, without the rigorous research experience required of a Ph.D.
Repeat rules: May be repeated for credit.

NBIO 994. Doctoral Research and Dissertation. 3 Credits.