PHARMACOLOGY (PHCO)

All preceding courses in chemistry, biology, bacteriology, and physiology in the Pharmacy School curriculum or their equivalent. A course for pharmacy students. Drug pharmacodynamics of major drug classes and organ systems will be stressed.

A course for pharmacy students. Drug pharmacodynamics of major drug classes and organ systems will be stressed.

A combined lecture/laboratory workshop for serious students of protein crystallography. Course intended primarily for graduate students.

Permission of the instructor. A first-year pharmacology course outlining the basics of molecular pharmacology, including molecular biology, drug and receptor interactions, receptors and ion channels, regulation of second messengers, and drug metabolism. Three lecture hours a week.

Introduces students to the major areas of pharmacology and physiology and serves as a basis for more advanced courses. Three lecture hours a week.

Basic principles of pharmacology and behavior analysis are considered in relation to drugs that affect the central nervous system.

Cellular and physiological basis of toxicity of environmental chemicals, with emphasis on inhalation toxicology, developmental toxicology, immunotoxicology, radiation toxicology, renal toxicology, and neurotoxicology. Three lecture hours per week.

Required preparation, advanced graduate or advanced undergraduate courses in biochemistry and molecular biology. This course deals with the molecular and cellular basis of anticancer and antiviral chemotherapy, with emphasis on novel approaches including immunotherapy, antisense oligonucleotides, and gene therapy. The course includes faculty lectures and student presentations.

This is a series of seminar courses dealing with advanced topics in modern molecular pharmacology based mainly on discussion of current literature.

Lecture/discussion course on the physiology, pharmacology, biochemistry, and molecular biology of the nervous system. Topics include function and structure of ion channels, neurotransmitter biosynthesis and release mechanisms, neurotransmitter receptors, and intracellular signaling pathways.

Permission of the department. This course explores the experimental and theoretical function of the nervous system. Typically, the first hour is fundamental material presentation and the second hour may be a presentation led by the students. Topics covered include: cellular diversity in the CNS, gross brain anatomy, human and rodent brain imaging, neuromolecular genetics, behavioral methods, membrane potentials/resistance/capacitance, ion channel structure, electrophysiology and propagation of electrical signals in neurons. Basic undergraduate biology, chemistry, physics and intro calculus is assumed.

Permission of the department. Consideration of membrane receptor molecules activated by neurotransmitters in the nervous system with emphasis on ligand binding behavior and molecular and functional properties of different classes of receptors. Course meets for four weeks with six lecture hours per week.

Seminar/discussion course covering recent advances in the role of these proteins in signaling and growth.

Seminar/discussion course on molecular aspects of the receptors, G-proteins, effector proteins, kinases, and phosphatases that mediate hormone, neurotransmitter, growth factor, and sensory signaling.

Examines the growing number of families of cell adhesion receptors and their role in biological processes including signal transduction, control of gene expression, hemostasis, cancer, neuronal development, immunobiology, and embryologic development.

Seminar/discussion course on the physiology, pharmacology, biochemistry, and molecular biology of ion channel proteins.

A lecture/discussion course on the biological bases of alcohol and substance abuse.

A seminar/discussion course on recent advances in targeted gene delivery and gene therapy.

Students meet as a group with faculty members to develop skills in critical reading and to summarize and discuss selected aspects of current pharmacological literature. Two hours a week. Fall and spring.

This graduate-level course encompasses both seminars presented by distinguished faculty from UNC, Duke, and other high-level research institutions, and seminars presented by students in the Pharmacological Sciences Training Program (PSTP) to other PSTP students and faculty. Students are required to attend at least 80% of these seminars each semester.

A discussion course covering the elements of successful grant proposals and scientific ethics.

A seminar/discussion course on the research, development, and regulatory processes involved in bringing new drugs to clinical use.

A lecture/discussion course on pain transmission and pain measurement. The neuropharmacological basis of pain modulation will be discussed.

Lecture/discussion course covering a variety of aspects of new biological and computational technologies. The course is predominantly in a lecture format with computer-based and literature assignments.

A seminar/discussion course to evaluate the use of small molecule inhibitors of protein kinases from a structural and signal transduction perspective.

A lecture/discussion course that emphasizes preclinical and clinical studies for the development of anti-cancer drugs that target signal transduction. Topics include: target identification and validation, drug discovery, the process of government approval for clinical trials, design of clinical trials, and new genetic-based technologies to foster drug development.

This course offers an introduction to the nascent interdisciplinary field of nanomedicine for students with physical/biological science backgrounds; course will be based on student led discussions of current literature.

The objective of this new elective is to provide graduate students with an overview of stem cell biology with a unique emphasis on the applications of stem cells in pharmacology, particularly in areas of cancer and tissue regeneration.

Required preparation, coursework in biochemistry, pharmacology and/or cell & molecular biology. Permission of the instructor. This graduate-level course is an in-depth analysis of how protein kinases and protein phosphorylation regulates key aspects of cell signaling. This class is one of the "Contemporary Topics in Cell Signaling" modules.

Required preparation, coursework in biochemistry, pharmacology, and/or cell & molecular biology. Permission of the instructor. This graduate-level course conveys principles of signal transduction controlled by GTPases and emphasizes in-depth discussion of current literature and unanswered questions. This class is one of the "Contemporary Topics in Cell Signaling" modules.

Permission of the instructor. Required preparation, coursework in biochemistry and/or cell & molecular biology. This graduate-level course conveys principles of eukaryotic cell proliferation control emphasizing in-depth discussion of current literature and unanswered questions. This class is one of the Contemporary Topics in Cell Signaling modules.

Acquire the scientific vocabulary of the signaling network field. Master key concepts from mathematical characterization of signaling circuits. Develop and apply critical analysis skills.

Required preparation, coursework in genetics, cell biology, and molecular biology. Permission of the instructor. Course addresses key issues in developmental biology focused on the role of stem cells and emphasizes in-depth discussion of current literature and unanswered questions. One of the Contemporary Topics in Cell Signaling modules.

This graduate-level course concentrates on up-to-date views of intercellular signal processing, with emphasis on signal transduction mechanisms as they relate to cellular/physiological responses in both normal development and disease. Signaling mechanisms that will be discussed include autocrine, paracrine, juxtacrine signaling and cell-matrix interactions.

This course will introduce computer vision methods for cell biology. Each topic will be motivated with an explanation of a computational challenge, followed by a discussion of available techniques to address the need and practical examples for how to apply the techniques.

Overview of structures and biological determinants of conditions and diseases of the oral cavity. Both growth and development and pathophysiology will be introduced in the context of three areas of oral biology: biology of extracellular matrices, host-pathogens interactions, and orofacial neurobiology.

This is a clinician-taught course that advances students' understanding of chronic pain (e.g., head/face pain, pelvic pain, back pain, cancer pain, surgical pain) in both the classroom and the clinic.

This course is designed to familiarize students with everything needed to run an RNA-Seq experiment. There will be minimal emphasis on theory and heavy focus on practical aspects. There are no formal prerequisites required for this course and no prior experience with UNIX or the command line interface is expected.

This course will familiarize graduate students with the fundamental concepts of mass spectrometry-based proteomics with emphasis on its applications (expression proteomics, post-translational modification identification, and interactomics) and practical aspects of these applications, such as experimental design, sample preparation and data interpretation. This course is intended for 2nd year students and above who currently use or plan to use proteomics in their research.

A combined lecture/laboratory workshop for serious students of protein crystallography. Course intended primarily for graduate students.

Permission of the department.

Permission of the department. Research in various aspects of neurobiology. Six to 24 hours a week.

Permission of the department.

Permission of the department.